Home / Transmissible spongiform encephalopathies : a Neverendingstory?

 

Veterinary & Comparative Pathology Seminar Series 2013

R(D)SVS Veterinary Pathology Unit in association with the British Society of Veterinary Pathology present:

Seminar Room B.006, Roslin Institute, Easter Bush Campus, 16.00 – 17.00.

Seminar coordinator: Sionagh Smith

Transmissible spongiform encephalopathies : a Neverendingstory?

Thursday 7th March 20132 RCPath CPD creditsFrancesca Chianini

Although the confirmation of the protein only hypothesis represented a significant step forward for TSE science, it made the strain phenomenon and transmissibility between species more difficult to explain. We have tested a large number of strains/challenge species transmission and performed a two passage study on the susceptibility of rabbits to in vitro generated species homologous disease associated prion infection.

Prior to this study there were many uncertainties with respect to the susceptibility of rabbits to TSEs; previous in vivo studies had failed to transmit the disease yet the success of our in vitro and in vivo studies proved that rabbit PrP could be efficiently misfolded and cause disease.